KMID : 0355220070320010045
|
|
Journal of Korean Academy Oral Medicine 2007 Volume.32 No. 1 p.45 ~ p.55
|
|
Antibacterial Effect on Oral Pathogenic Bacteria of Phytoncide from Chamaecyparis Obtusa
|
|
Kang Soo-Kyung
Shin Mi-Kyoung Auh Q-Schick Chun Yang-Hyun Hong Jung-Pyo
|
|
Abstract
|
|
|
Plant extract has attracted considerable interest in oral disease therapy. The present study was performed to observe the antibacterial effect on cariogenic Streptococcus mutans GS5 and Streptococcus sobrinus 6715, and periodontopathic Actinobacillus actinomycetemcomitans Y4 of phytoncide from Chamaecyparis obtusa Sieb. et Zucc employing the measurement of optical density, viable cell counts, and antibiotic sensitivity. The results were as follows:
1. Minimum inhibitory concentration of the phytoncide for S. mutans, S. sobrinus, and A. actinomycetemcomitans was observed to be 0.5%, 1%, and 0.2%, respectively.
2. Minimum bactericidal concentration of the phytoncide for S. mutans, S. sobrinus, and A. actinomycetemcomitans was determined to be 0.5%, 2%, and 0.2%, respectively.
3. The bacteria exposed to the phytoncide become more sensitive to antibiotics. The phytoncide enhanced significantly antibacterial activity of ampicillin against S. mutans and S. sobrinus. It also increased significantly the activity of penicillin and amoxicillin against S. sobrinus. In contrast, the phytoncide augmented the activity of amoxicillin and cefotaxime against A. actinomycetemcomitans but the increase was not statistically significant.
The overall results indicate that phytoncide from Chamaecyparis obtusa Sieb. et Zucc used for this study has a strong antibacterial activity against cariogenic and periodontopathic bacteria and that it also has permeabilizing effect on certain antibiotics against these bacteria. Therefore, the phytoncide may be used as a candidate for prevention and therapeutic agent against oral infectious disease including dental caries and periodontal disease.
|
|
KEYWORD
|
|
Phytoncide, Antibacterial effect, Dental caries, Periodontal disease, Oral pathogenic bacteria
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|